The uneven distribution of cell staining and the diversity of tissue morphologies bring challenges to the automatic segmentation of Hematoxylin-Eosin (HE) stained pathological images. In order to solve the problem, a three-step hierarchical segmentation method of pathological images based on self-supervised learning was proposed to automatically segment the tissues in the pathological images layer-by-layer from coarse to fine. Firstly, feature selection was performed in the RGB color space based on the calculation result of mutual information. Secondly, the image was initially segmented into stable and fuzzy color regions of each tissue structure based on K -means clustering. Thirdly, the stable color regions were taken as training datasets for further segmentation of fuzzy color regions by naive Bayesian classification, and the three complete tissue structures including nucleus, cytoplasm and extracellular space were obtained. Finally, precise boundaries between nuclei were obtained by performing the mixed watershed classification considering both shape and color intensities to the nucleus part, so as to quantitatively calculate the indicators such as the number of nuclei, nucleus proportion, and nucleus-cytoplasm ratio. Experimental results of HE stained meningioma pathological image segmentation show that， the proposed method is highly robust to the difference of staining and cell morphologies, the error of issue area segmentation is within 5%, and the average accuracy of the proposed method in nucleus segmentation accuracy experiment is above 96%, which means that the proposed method can meet the requirements of automatic analysis of clinical images and its quantitative results can provide references for quantitative pathological analysis.

Aiming at improving the users' high viscosity in social networks, an algorithm based on user loyalty in social network system was proposed. In the proposed algorithm, double Recency Frequency Monetary (RFM) model was used for mining the different loyalty kinds of users. Firstly, according to the double RFM model, the users' consumption value and behavior value were calculated dynamically and the loyalty in a certain time was got. Secondly, the typical loyal users and disloyal users were found out by using the founded standard curve and similarity calculation. Lastly, the potential loyal and disloyal users were found out by using modularity-based community discovery and independent cascade propagation model. On some microblog datasets of a social network, the quantitative representation of user loyalty was confirmed in Social Network Service (SNS), thus the users could be distinguished based on users' loyalty. The experimental results show that the proposed algorithm can be used to effectively dig out different loyalty kinds of users, and can be applied to personalized recommendation, marketing, etc. in the social network system.

To improve the accuracy of traditional method for customer segmentation, the Large Average Submatrix (LAS) biclustering algorithm was used, which performed clusting on customer samples and consumer attributes simultaneously to identify the upscale and high-value customers. By introducing a new value yardstick and a novel index named PA, the LAS biclustering algorithm was compared with K-means clustering algorithm based on a simulation experiment on consumption data of a telecom corporation. The experimental result shows that the LAS biclustering algorithm finds more groups of high-value customers and obtains more accurate clusters. Therefore, it is more suitable for recognition and segmentation of high-value customers.